Using AES.MODE_EAX for AES Encryption

I am currently attempting to perform AES encryption in Python on a larger size file for simulation purposes. At the moment, I have been trying to use AES.MODE_EAX, as mentioned in the documentation for AES:

https://pycryptodome.readthedocs.io/en/latest/src/cipher/aes.html

I wanted to check what the correct way of approaching encryption of the file would be.

At the moment, I am dividing the file into 16 byte chunks, and using the same 128 bit key for creating a cipher in order to encrypt each chunk. I am running the following commands on each chunk as needed for encryption, and I am performing analysis on the encrypted results:

cipher = AES.new(key, AES.MODE_EAX)
nonce = cipher.nonce
ciphertext, tag = cipher.encrypt_and_digest(data_chunk)

I am not sure if my understanding is thorough. Would this be a valid approach towards encrypting the data via AES? Or are there other modes or approaches with MODE_EAX (like using the data of the full file?) that I should consider in this case?

You do not have to divide the data into 16-byte blocks and individually encrypt each block. The encrypt_and_digest method will handle all of this division for you. Instead you should call the method on the full array of data.

By individually enciphering each block you are creating a nonce and tag for each block rather than a single nonce and tag for all of your data. Even for moderate sized data this will roughly triple the size of your cryptogram. The only real benefit to producing one tag per blocks that if the integrity of the message is compromised, you can narrow down the change to which block it occurred in.

As noted in the comments AES.GCM is generally preferred over AES.EAX in modern implementations.