how are files split and saved into the stripe? one file per stripe
(the remaining strips are filled with zeros) or many files for a
stripe until it all its strips are filled?
Arrays like this don't think in terms of files, just blocks, the filesystem itself defines what files are made up of what blocks, it's not the underlying disk system that does that.
So don't think of it as files just blocks, imagine all the files on your filesystem but take away all the data about folders and files, it's just one big pile of blocks - and it's those blocks that get striped across available disks for performance and resilience.
Generally speaking the default for file systems and RAID arrays like this will fit 95% of all applications just fine. The ability to tune them is great if you have the time to play about and test all the various combinations or if you have an application that has unusual requirements (such as it constantly reading or writing either lots of tiny random files or at the other end huge sequential files) - in those cases then yes some of the tuning can have significant benefits. But again generally speaking the defaults are usually pretty good for most use cases. I do VoD so we do often tune our storage volumes to have very large strips/blocks because we know they're all large sequential files, but then we don't put our DB files or logs etc. on those arrays/volumes because they'd be terrible for that use.
Anyway back to recommendations, glad you seem to have settled on R60 - we get people here all the time with issues with R5/50, it's dead, don't use it at all - R6/60 and R1/10 are the only game in town, unless you have a boner for ZFS anyway :) - anyway if I was doing this I'd do exactly what you suggest - R60 made up of 2 x 12-disk R6's, leave the stripe at defaults and then as your application starts to make use of this array you can look at how it's performing and if you really feel you need to tune it and will get a lot of benefit from doing so then go ahead, but I bet you'll be just fine with the defaults.
Best of luck.