That should be fine. As long as the records relating to email match up in both directions, you can have other DNS records pointing to different IP addresses all you want.
For instance quite a common scenario would be to have inbound email delivered to mail.sub.domain.tld
on one IP address, and a website hosted on a different server/IP address pointing to www.sub.domain.tld
and sub.domain.tld
.
Obviously if you're sending from the mail.sub.domain.tld
IP(s), and also have the website sending emails (for instance contact forms), then you'd need to ensure that both of them are included in your SPF record, so receiving servers see both as valid email sources.
The same is true for domain.tld
, as you'd have separate MX / A / SPF records for that domain level, so they wouldn't impact each other. For instance mail.sub.domain.tld
and mail.domain.tld
could have completely different setups and DNS records without negatively interacting with each other.
If a receiving server got an email from [email protected]
it will specifically look in sub.domain.tld
for an SPF record, not in the root domain.tld
domain that could be configured with completely different details.