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Ubuntu 20.04 alsamixer protocol error for Scarlet 6i6, and no sound

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I get a protocol error message when I try to open my Scarlett 6i6 preamp, connected via USB, on Ubuntu 20.04. Works just fine on Ubuntu 18.04, on another computer.

cannot load mixer controls: Protocol error

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At the same time, pavucontrol shows the device, and it is playing something, but nothing is audible:

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Is there a way to fix sound, or debug what's going on?

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